| Sarnak Summoners Staff | The Ruins of Kunark | KUNARK Raid 65 Pool 1 |
| Scalp of the Ghoul Lord | Original EverQuest (Classic) | CLASSIC Named 47 Pool 9 |
| Scarab Ring | Original EverQuest (Classic) | CLASSIC Named 16 Pool 3 |
| Scepter of the Shrine | The Scars of Velious | VELIOUS Raid 70 Pool NA |
| Sceptre of Destruction | The Scars of Velious | VELIOUS Raid 70 Pool 2 |
| Sceptre of Ixiblat Fer (CLR EPIC) | The Ruins of Kunark | KUNARK Raid 62 Pool 2 |
| Scimitar of the Emerald Dawn | The Scars of Velious | VELIOUS Raid 64 Pool 3 |
| Scimitar of the Ykesha | The Ruins of Kunark | KUNARK Raid 53 Pool 2 |
| Scuffed Silver Key | Original EverQuest (Classic) | CLASSIC Named 25 Pool 4 |
| Scute Shield | Original EverQuest (Classic) | CLASSIC Named 12 Pool 2 |
| Sea Dragon Meat | The Ruins of Kunark, The Scars of Velious | KUNARK Raid 55 Pool 1, VELIOUS Raid 66 Pool 2, VELIOUS Raid 65 Pool NA |
| Seahorse Scale Cloak | Original EverQuest (Classic) | CLASSIC Named 47 Pool 9 |
| Second Half of Al`Tarlkal's Tome | The Scars of Velious | VELIOUS Raid 99 Pool NA |
| Second Half of Vin'Pekir's Tome | The Scars of Velious | VELIOUS Raid 99 Pool NA |
| Section of Lodizal's Shell | The Scars of Velious | VELIOUS Raid 60 Pool 4 |
| Sepentskin Eyepatch | Original EverQuest (Classic) | CLASSIC Named 14 Pool 2 |
| Serpent Blood Potion | Original EverQuest (Classic) | CLASSIC Named 14 Pool 2 |
| Serpent Insignia Collar | Original EverQuest (Classic) | CLASSIC Named 22 Pool 4 |
| Serpents Tooth | Original EverQuest (Classic) | CLASSIC Raid 56 Pool 2 |
| Serrated Symbol | The Scars of Velious | VELIOUS Raid 60 Pool 4 |
| Serrated Tear | The Scars of Velious | VELIOUS Raid 66 Pool 2 |
| Shard of Golem Stone | Original EverQuest (Classic) | CLASSIC Named 30 Pool 5 |
| Shard of Hsagra's Talisman | The Scars of Velious | VELIOUS Raid 70 Pool 1, VELIOUS Raid 59–66 Pool 3, VELIOUS Raid 70 Pool 4 |
| Shard of Night | The Ruins of Kunark | KUNARK Raid 62 Pool 2 |
| Sharkbone Warhammer | Original EverQuest (Classic) | CLASSIC Named 46 Pool 9 |
| Sharkjaw Cutlass | Original EverQuest (Classic) | CLASSIC Named 49 Pool 9 |
| Sharpened Dragon's Scale | The Scars of Velious | VELIOUS Raid 70 Pool 2 |
| Shield of Elders | The Ruins of Kunark | KUNARK Raid 70 Pool 1 |
| Shield of Prexus | Original EverQuest (Classic) | CLASSIC Named 47 Pool 9 |
| Shield of the Clawed Guardian | The Scars of Velious | VELIOUS Raid 70 Pool 2 |
| Shield of the Freezing Winds | The Scars of Velious | VELIOUS Raid 66 Pool 3 |
| Shield of the Green Dragon | The Ruins of Kunark | KUNARK Raid 60 Pool 1 |
| Shield of the Immaculate | Original EverQuest (Classic) | CLASSIC Raid 55 Pool 2 |
| Shield of the Red Dragon | The Ruins of Kunark | KUNARK Raid 60 Pool 1 |
| Shield of the Seneschal | The Scars of Velious | VELIOUS Raid 65 Pool NA |
| Shield of the Water Dragon | The Ruins of Kunark | KUNARK Raid 55 Pool 1 |
| Shield of the White Dragon | The Ruins of Kunark | KUNARK Raid 60 Pool 1 |
| Shimmering Bauble of Trickery | The Scars of Velious | VELIOUS Raid 75 Pool NA |
| Shimmering Orb | Original EverQuest (Classic) | CLASSIC Named 21 Pool 4 |
| Shiny Brass Halberd | Original EverQuest (Classic) | CLASSIC Named 21 Pool 4 |
| Shiny Brass Idol | Original EverQuest (Classic) | CLASSIC Named 22 Pool 4 |
| Shiny Golden Coin | Original EverQuest (Classic) | CLASSIC Named 10 Pool 1 |
| Shiny Silk Gloves | Original EverQuest (Classic) | CLASSIC Named 10 Pool 1 |
| Shissar Deathspeaker Staff | The Ruins of Kunark | KUNARK Raid 65 Pool 1 |
| Shissar Focus Staff | The Ruins of Kunark | KUNARK Raid 65 Pool 1 |
| Shissar Guardian Staff | The Ruins of Kunark | KUNARK Raid 55 Pool 1 |
| Shissar Nullifier Staff | The Ruins of Kunark | KUNARK Raid 55 Pool 1 |
| Shissar Protection Staff | The Ruins of Kunark | KUNARK Raid 65 Pool 1 |
| Shovel of the Harvest | The Scars of Velious | VELIOUS Raid 66 Pool 3 |
| Shralok Pack | Original EverQuest (Classic) | CLASSIC Named 21 Pool 4 |
| Shrieking Ahlspiess | Original EverQuest (Classic) | CLASSIC Raid 56 Pool 2 |
| Shroud of Longevity | The Scars of Velious | VELIOUS Raid 70 Pool 2 |
| Shroud of Veeshan | The Ruins of Kunark | KUNARK Raid 70 Pool 1 |
| Sightless Velium Eye | The Scars of Velious | VELIOUS Raid 70 Pool 2 |
| Signet of the Shrine | The Scars of Velious | VELIOUS Raid 70 Pool NA |
| Silver Girdle of Stability | The Scars of Velious | VELIOUS Raid 66 Pool 3 |
| Silver Symbol | The Scars of Velious | VELIOUS Raid 60 Pool 4 |
| Silver Tear | The Scars of Velious | VELIOUS Raid 66 Pool 2 |
| Silver Wolf Totem | Original EverQuest (Classic) | CLASSIC Named 35 Pool 6 |
| Silver-Plated Bracer | Original EverQuest (Classic) | CLASSIC Named 30 Pool 5 |
| Silverish Scimitar | Original EverQuest (Classic) | CLASSIC Named 22 Pool 4 |
| Singed Scroll | The Ruins of Kunark | KUNARK Raid 65 Pool 2 |
| Singing Steel Breastplate | The Ruins of Kunark | KUNARK Raid 65 Pool 1 |
| Singing Steel Greaves | The Ruins of Kunark | KUNARK Raid 55 Pool 1 |
| Siryn Hair Hood | Original EverQuest (Classic) | CLASSIC Named 34 Pool 6 |
| Skull of Jhen'Tra | Original EverQuest (Classic) | CLASSIC Named 15 Pool 2 |
| Skullcrusher of Kragg | The Ruins of Kunark | KUNARK Raid 65 Pool 1 |
| Skydarkener | The Scars of Velious | VELIOUS Raid 64 Pool 3 |
| Slime Blood of Cazic Thule | Original EverQuest (Classic) | CLASSIC Raid 55 Pool 2 |
| Slime Crystal Staff | Original EverQuest (Classic) | CLASSIC Named 25 Pool 4 |
| Slowstone Amber | Original EverQuest (Classic) | CLASSIC Raid 56 Pool 2 |
| Small Bone Shield | Original EverQuest (Classic) | CLASSIC Named 14 Pool 2 |
| Small Stone Key | Original EverQuest (Classic) | CLASSIC Named 21 Pool 4 |
| Smolder | The Scars of Velious | VELIOUS Raid 70 Pool 2 |
| Smoldering Brand | Original EverQuest (Classic) | CLASSIC Named 54 Pool 10 |
| Smoldering Cudgel | The Ruins of Kunark | KUNARK Raid 65 Pool 1 |
| Snow Storm Mask | The Scars of Velious | VELIOUS Raid 66 Pool 3 |
| Sode of Empowerment | Original EverQuest (Classic) | CLASSIC Raid 56 Pool 2 |
| Sontalak's Talisman | The Scars of Velious | VELIOUS Raid 70 Pool 3 |
| Soul Defiler | The Scars of Velious | VELIOUS Raid 70 Pool 1 |
